DOI: https://doi.org/10.55373/mjchem.v28i2.270

Keywords: Creatine Kinase (CK-MB), myocardial infarction (MI), binary CuO\CoO nanoparticles

Abstract

Nanoparticles have emerged as effective tools in various applications, including medicine, due to their ability to overcome organic barriers and enhance targeted therapy. This study investigates the effect of cobalt oxide/copper oxide (CoO/CuO) divalent nanoparticles on creatine kinase-MB (CK-MB) levels in the serum of patients with myocardial infarction. The CoB/CuO divalent nanoparticles were produced via photoluminescence irradiation and characterized using XRD, TEM, SEM, and EDX techniques, confirming their crystalline structure and average size, which ranged from 16 to 35 nm. Patients with myocardial infarction had significantly higher serum CK-MB levels (30.49 ± 1.35 U/L) compared to the control group (17.28 ± 4.06 U/L; P < 0.0001). In this study, the activity of CoO/CuO nanoparticles was found to be concentration-dependent in inhibiting CK-MB activity, with inhibition reaching up to 57% at 0.05 M. These results indicate that CoO/CuO binary nanoparticles have a modulating effect on CK-MB activity, confirming their potential for developing nanoparticle-based therapeutic approaches for myocardial infarction.