DOI: https://doi.org/10.55373/mjchem.v27i1.195

Keywords: 3-Acylindole; diethyl aluminum chloride; Friedel-Crafts acylation; 5-substituted indole; tin (IV) chloride

Abstract

Indole has long stood as a pivotal structural backbone in numerous biologically potent natural compounds and pharmaceuticals. While several synthetic strategies have been developed to construct this framework with reasonable yields, certain obstacles have been encountered. Building upon previous investigations, this study unveils a robust and efficient method to synthesize the 3-acylindole core, utilizing various Lewis acids depending on the nature of the substituent at the C5 position of the indole ring.