DOI: https://doi.org/10.55373/mjchem.v27i1.274

Keywords: Bibenzyls; synthesis; biological activity; enzymes

Abstract

A class of chemical compounds which are obtainable from natural sources, known for their distinct molecular structure and wide range of biological actions are called bibenzyls. The synthesis, structural variety, and therapeutic qualities of bibenzyls are examined in this review, with an emphasis on their applicability to drug development and discovery. The reported synthesis shows promising yields in correspondence to different derivatives. The potential applications of bibenzyl derivatives in pharmaceutical research are highlighted through a discussion of the structural motifs and synthetic techniques utilized during their manufacture. In order to clarify their modes of action and therapeutic potential, bibenzyls' biological activities such as their antimicrobial, cytotoxic, enzyme assay and acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are also investigated. According to Wang et al. [17], antimicrobial activity shows potential as there was no bacteria growth in triplicate wells. Cytotoxic activity confirms that bibenzyls are able to cause apoptosis in various cancer cells. Enzyme assays show excellent tyrosinase inhibitory activity as it has an IC₅₀ of 1.6 µm which is five times more potent than kojic acid. Acetylcholinesterase inhibitor is one of the most promising inhibitors with IC₅₀ = 0.096 µm. The subject of bibenzyl research is finally summarized with an emphasis on future directions and present trends. This highlights the significance of ongoing research and innovation in order to fully utilize these chemicals for biological and pharmacological developments.