DOI: https://doi.org/10.55373/mjchem.v27i1.181

Keywords: Daibucarboline A; anti-inflammatory; tetrahydro-β-carboline intermediates

Abstract

Daibucarboline A, a notable compound with demonstrated anti-inflammatory properties, has garnered significant interest due to its potential therapeutic applications. This short review explores the synthetic strategies employed to develop Daibucarboline A and its derivatives, focusing on the role of tetrahydro-β-carboline intermediates in their preparation. We summarize recent advancements in the synthesis of these intermediates, which are crucial for constructing the daibucarboline scaffold. The review highlights key methodologies used to achieve efficient and selective synthesis of tetrahydro-β-carboline derivatives and their subsequent transformation into bioactive daibucarboline compounds. Additionally, we review the anti-inflammatory potential of Daibucarboline A and its derivatives in vitro and in vivo studies that elucidate their mechanisms of action. By providing a comprehensive overview of the synthesis and bioactivity of these compounds, this review aims to offer insights into the development of novel anti-inflammatory agents based on the daibucarboline framework and to identify future directions for research in this promising area.