DOI: https://doi.org/10.55373/mjchem.v24i4.89

Keywords: Imidazole, Carbene, Silver, Ae-aegypti, Culex quinquefasciatus

Abstract

A series of aromatic nitrile functionalized imidazolium salts has been synthesized by the successive N-alkylation method. Subsequently, silver(I) complexes incorporated with N-heterocyclic carbene (NHC) ligands have been synthesized by the treatment of imidazolium salts with Ag2O at mild reaction conditions. Both salts and Ag(I)-NHC complexes have been characterized by 1H and 13C NMR, FTIR spectroscopy and elemental analysis techniques. The molecular structure of salt 2 was elucidated through single crystal -XRD analyses. The larvicidal studies against Aedes aegypti and Culex quinquefasciatus, show that complex 6 has the highest larval mortality with LC50 of 27.90 and 30.27 ppm, respectively, compared to the synthesized complexes 4 and 5. Meanwhile, all the NHC salts proved to be inactive biological activities compared with their respective complexes, indicating the utility of silver (I) ions in larvicidal applications.