DOI: https://doi.org/10.55373/mjchem.v24i4.173

Keywords: Lauraceae, Beilschmiedia, Endiandra, Cyclic polyketides, Endiandric acids, Kingianins

Abstract

The genus Beilschmiedia and Endiandra which are belong to the Lauraceae family, has been used extensively in traditional treatment. A rare class of tetracyclic and pentacyclic metabolites (i.e endiandric acids and the kingianin series) have been isolated and found specifically in these Beilschmiedia and Endiandra species. This current mini review is an update from the years 2000 ‒ 2022 on phytochemical studies and biological activities together with the biosynthesis of the secondary metabolites from both genera. Previous literature reported that the chemical compounds from these two genera possess good biological activities such as anti-allergic, anti-asthmatic, anti-inflammatory, anti-bacterial, anti-tuberculosis, anti-plasmodial, anti-diabetic and anti-proliferative. The literatures and reference for this manuscript were obtained from various sources including SciFinder®, Reaxys®, ScienceDirect®, PubMed Central®, NIH National Library of Medicine, Google Scholar and The Plant List®. This review provides the update regarding the chemical structures, biological activities and biosynthesis of cyclic polyketides specifically in Beilschmiedia and Endiandra genera.