Keywords: Cyclodextrin; ternary complex; inclusion complex; pharmaceutical drugs

Abstract

Drug dependence and tolerance has become a major issue related to human health and significantly affects people living in the world today. Cyclodextrins (CDs), a family of cyclic oligosaccharides, have been widely used in the field of pharmaceutical sciences to formulate host-guest inclusion complexes with desired pharmaceutical drugs in order to improve their bioavailability and absorption by the human body. To further enhance the properties of CD-drug binary inclusion complexes, the formulation of ternary CD-drug inclusion complexes with an additive (for example polymers, organic acids, amino acids, and co-solvents) as the ternary component have been vastly explored by researchers worldwide. This review article offers a brief but comprehensive overview on various applicable synthesis and characterization methods employed by researchers for the formulation of ternary inclusion complexes of cyclodextrins with pharmaceutical drugs.