Synthesis, Characterization and Antibacterial Studies of Nickel(II) and Palladium(II) Complexes of Thiosemicarbazone
Abstract
A series of four benzaldehyde derivatives have been synthesized and underwent complexation with Ni(II) and Pd(II) ions using a microwave-assisted method. All compounds were characterized structurally using CHNS, FT-IR, and 1H and 13C-NMR spectroscopies. The results from FT-IR and NMR spectroscopies showed that the thiosemicarbazone ligands bind to the thionic sulfur and azomethine nitrogen. The antibacterial activities of the compounds were first tested by the broth microdilution method against two Gram-positive and three Gram-negative bacteria. Then, the minimum inhibitory concentration (MIC) was determined using gentamicin as a reference drug. The tested compounds showed significant activity to both types of tested bacteria compared to gentamicin.
Published 29 September 2020
Issue Vol 22 No 3 (2020): Malaysian Journal of Chemistry
Section Article