MALAYSIAN JOURNAL OF CHEMISTRY (MJChem)

MJChem is double-blind peer reviewed journal published by the Malaysian Institute of Chemistry (Institut Kimia Malaysia) E-ISSN: 2550-1658

A Facile Synthesis of 2-Hydroxy-3-Phenylquinoline Derivatives

Nepolraj Amaladoss
Department of Chemistry, Annai College of Arts and Science, Kovilacheri, Kumbakonam, Tamilnadu 612503, India
Pitchai Pandian
Department of Chemistry, Government Arts college (Autonomous), Kumbakonam, Tamilnadu 612002, India
Vijayarathinam Manickam
Department of Chemistry, Anna Government Arts College, Vadachennaimalai, Attur, Tamilnadu 636121, India

Keywords: Bechamp reduction, phenylethylacetate, 3-phenylquinoline-2-ol, chemo-selective, microwave

Abstract

A mild and efficient way for the synthesis of 3-phenylquinoline-2-ol derivatives via chemo-selective reaction of substituted O-nitrobenzaldehyde and ethyl-2-phenylacetate catalyzed by Fe/HCl is described. The new procedure has the advantages of mild reaction conditions, high yields and one-pot manner with easy purification, and further characterised by NMR, FT-IR and HRMS spectral data.

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Published 31 December 2019

Issue Vol 21 No 3 (2019): Malaysian Journal of Chemistry

Section Article

Announcement

UPDATE: A new issue has been published; Vol 26 No 2 (2024)

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