Keywords: Vibrational spectroscopy; anti-cancer nanopharmaceuticals; spectroscopy techniques; nanocompounds; nanomaterials; mid-infrared spectroscopy; near-infrared spectroscopy; attenuated total reflectance-Fourier transform infrared spectroscopy; Raman spectroscopy

Abstract

The nuclear magnetic resonance (NMR) and mass spectrometry (MS) are two important, widely used spectroscopy methods for chemical structure elucidation of previously unknown nanocompounds in the pharmaceutical industry. At the other hand, mid-IR (MIR) and near–infrared (NIR) spectroscopy remained as key techniques in development, quality control (QC), and process analytics as well as for solid form characterization or minimal sample preparation. As a result of recent technical advances, Raman spectroscopy is now considered as one of the most important methods used in pharmaceutical research and development (R&D) environments. Therefore, it can be said that the identification, characterization, and investigation of pharmacologically active and related nanocompounds as discrete nanomaterials and in formulated products are typically performed using mid-IR, NIR, and Raman spectroscopy.