Keywords: Alkaloids, Alseodaphne corneri, Lauraceae

Abstract

The isolation and purification of the leaves extract of Alseodaphne corneri Kosterm yielded four alkaloids; norisocorydine 1, isocorydine 2, 2-norobamegine 3 and obamegine 4. This phytochemical study involves extraction, separation by using various chromatographic methods and structural determination by spectroscopic technique such as ultraviolet spectroscopy (UV), infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR) including 1D-NMR ( 1H, 13C and DEPT), 2D-NMR (COSY, NOESY, HMQC/HSQC, and HMBC) and mass spectrometry (MS). The IC50 value of antiplasmodial activity for isocorydine 2 and obamegine 4 are 0.50 µmolL-1 and 0.14 µmolL-1 respectively.