A Facile Synthesis of 2-Hydroxy-3-Phenylquinoline Derivatives

  • Nepolraj Amaladoss Department of Chemistry, Annai College of Arts and Science, Kovilacheri, Kumbakonam, Tamilnadu 612503, India
  • Pitchai Pandian Department of Chemistry, Government Arts college (Autonomous), Kumbakonam, Tamilnadu 612002, India
  • Vijayarathinam Manickam Department of Chemistry, Anna Government Arts College, Vadachennaimalai, Attur, Tamilnadu 636121, India
Keywords: Bechamp reduction, phenylethylacetate, 3-phenylquinoline-2-ol, chemo-selective, microwave


A mild and efficient way for the synthesis of 3-phenylquinoline-2-ol derivatives via chemo-selective reaction of substituted O-nitrobenzaldehyde and ethyl-2-phenylacetate catalyzed by Fe/HCl is described. The new procedure has the advantages of mild reaction conditions, high yields and one-pot manner with easy purification, and further characterised by NMR, FT-IR and HRMS spectral data.