Synthesis and Nuclear Magnetic Resonance Studies of 2-Thiophenecarboxaldehyde Nicotinic Hydrazone and 2-Thiophenecarboxaldehyde Benzhydrazone
Synthesis and NMR spectral studies of bidentate N and S heterocycles of 2-thiophenecarboxaldehyde nicotinic hydrazone and 2-thiophenecarboxaldehyde benzhydrazone have been carried out. The compounds, 2-thiophenecarboxaldehyde nicotinic hydrazone and 2-thiophenecarboxaldehyde benzhydrazone were synthesized by reacting stoichiometric quantities of nicotinic hydrazide and benzhydrazide with 2-thiophene carboxaldehyde in methanol in the presence of glacial acetic acid at refluxing temperature. Upon cooling the reaction mixture, the products were obtained as colorless solids. 1H, 13C, 1H-1H COSY, and 1H-13C HSQC experiments have been conducted to characterize the compounds.