Synthesis and Study of Biological Activities of Water-Soluble Derivatives of Metronidazole Based on Carbohydrate

  • Ehab K. Obaid Al-Qasim Green University
  • Wisam Abdul Jaleel Jawad University of Babylon
  • Ali Jabbar Radhi University of Al-Kafeel
  • Hayder Kadhim Abbas University of Al-Kafeel
Keywords: Metronidazole; antibacterial activities; solubility; 1,2,3-Triazole; click chemistry

Abstract

Conceptually, the present work will lead to preparation of new compounds with interesting characteristics for pharmaceutics due to increase in water solubility. Synthesis and study as potential antibacterial activity inhibitors of metronidazole–1,2,3-triazole ring based on carbohydrate are reported. All the prepared compounds of metronidazole were confirmed by NMR, FTIR elemental analysis, and mass spectroscopies. The compounds established potent to strong antibacterial activity against Gram-negative and Gram-positive bacteria. The tested compounds exhibited better antibacterial activities than the reference compound.

Published
2021-12-31