Malaysian Journal of Chemistry, 2017, Vol. 19(1), 33–58

Sesquiterpenes and Chromones of Agarwood: A Review

Daoud Tajeldeinn Ahmaed1* and Ajaykumar D. Kulkarni2
1Faculty of pharmacy, Pharmaceutical Chemistry Department, Omdurman Islamic university,Khartoum, Sudan
2Department of Applied Sciences, MIT Academy of Engineering (An Autonomous Institute Affi liated to Savitribai Phule Pune University), Dehu Phata, Alandi (D), Pune, 412105, India

*Corresponding author (e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.)

 Received: January 2017; Accepted: April 2017


This study is to characterize and profile the chemical constituents of Aquilaria species, mainly Aqularia malaccensis, Aqularia sinensis, and Aqularia crassna. This precious wood has long been used traditionally in religious ceremonies in the form of incense and oil. There are variations among the chemical group that has been identified in this species, mostly sesquiterpenoids, chromones and volatile aromatic compounds. Studies on the chemistry of agarwood smoke are discussed. Emphasis is given to structural and analytical aspects through this study. The agarwood grading system totally depended on its physical characteristics; there was no scientific approach based on the chemical profile which was used to classify the different grades of agarwood. A different type of analytical technique was used to isolate single pure compounds from chip wood of agarwood, and solvent refluxing was the most popular among them. The polar solvent was found to be used to obtain the polar compounds and chromium, while most of the sesquiterpene was obtained from the non-polar solvent. For extraction of agarwood, hydrodistillation was the most common technique to extract the oil and followed by supercritical fluid extraction, while steam distillation and Soxhlet distillation was rarely used. Different analytical instrumentation were used for the investigation of the chemical profile of agarwood such as GC-FID, GC-MS, GC-MS-OLF which were the most common research tools. The chemical profile of the wood from the different species and countries all looked different except the Vietnamese Aquilaria sinensis, and A. agallocha which seemed to have a very closed chemical profile. There were remarkable similarities in the chemical profile of A. agallocha India (wood ), A. agallocha Vietnam (wood), and A. sinensis Vietnam (wood) with the minor absence of some compounds from A. agallocha India (wood). From the literature, we could say that the 6-methoxy-2-[2-(4 -methoxypheny1)-ethyl]chromone and2-(2 (4methoxyphenyl)ethyl)chromone was the most dominate chromones found in all species.

Key wordsAquilaria malaccensis; Aquilaria sinensis; Aquilaria crassna; GC-FID; GC-MS; SPME; sesquiterpene


Hou, D. (1960) Thymelaeaceae, Flora Malesiana-Series 1, Spermatophyta, 6, 1−48

Yang, D.L., Wang, H., Guo, Z.K., Li, W., Mei, W. L. and Dai, H.F. (2014) Fragrant agarofuran and eremophilane sesquiterpenes in agarwood 'Qi-Nan' from Aquilaria sinensis, Phytochem Lett 8, 121−125.

Yagura, T., Shibayama, N., Ito, M., Kiuchi, F. and Honda, G. (2005) Three novel diepoxy tetrahydrochromones from agarwood artificially produced by intentional wounding, Tetrahedron Letters, 46, 4395−4398.

Wyn, L.T. and Anak, N.A. (2010) Wood for the Trees: A Review of the Agarwood (Gaharu) Trade in Malaysia, A TRAFFIC report to the CITES Secretariat, TRAFFIC Southeast Asia, Selangor, Malaysia.

Wong, Y.F., Chin, S.T., Perlmutter, P. and Marriott, P.J. (2015) Evaluation of comprehensive two-dimensional gas chromatography with accurate mass time-of-flight mass spectrometry for the metabolic profiling of plant-fungus interaction in Aquilaria malaccensis, J. Chromatogr, A 1387, 104−115.

Chua, L.S.L. (2008) Agarwood (Aquilaria malaccensis) in Malaysia, Forest Research Institute Malaysia.

Naef, R. (2011) The volatile and semi-volatile constituents of agarwood, the infected heartwood of Aquilaria species: a review, Flavour and Fragrance Journal, 26, 73−87.

Tajuddin, S.N. and Yusoff, M.M. (2010) Chemical composition of volatile oils of Aquilaria malaccensis (Thymelaeaceae) from Malaysia, Nat. Prod. Commun., 5, 1965−1968.

Lee, S. and Mohamed, R. (2016) Rediscovery of Aquilaria rostrata (Thymelaeaceae), a species thought to be extinct, and notes on Aquilaria conservation in Peninsular Malaysia, Blumea, 61, 13−19.

Soehartono, T. and Newton, A.C. (2001) Reproductive ecology of Aquilaria spp. in Indonesia, Forest Ecol Manag., 152, 59−71.

Compton, J. and Ishihara, A. (2004) The use and trade of agarwood in Japan, A TRAFFIC report to the CITES Secretariat, TRAFFIC Southeast Asia, Selangor, Malaysia.

Pripdeevech, P., Khummueng, W. and Park, S.K. (2011) Identification of odor-active components of agarwood essential oils from Thailand by solid phase micro-extraction-GC/MS and GC-O, Journal of Essential Oil Research, 23, 46−53.

Manohara, T.N. (2013) Wasp-mediated seed dispersal in agarwood plant (Aquilaria Malaccensis), a critically endangered and overexploited species of North East India, Current Science, 105, 298–299.

Ismail, N., Ali, N.A.M., Jamil, M., Rahiman, M.H.F., Tajuddin, S.N. and Taib, M.N. (2014) A review study of agarwood oil and its quality analysis, Jurnal Teknologi68.

Sen, S., Talukdar, N.C. and Khan, M. (2015) A simple metabolite profiling approach reveals critical biomolecular linkages in fragrant agarwood oil production from Aquilaria malaccensis ―a traditional agro-based industry in North East India, Current Scienc, 108, 63−71.

Antonopoulou, M., Compton, J., Perry, L.S. and Al-Mubarak, R. (2010) The trade and use of agarwood (Oudh) in the United Arab Emirates, TRAFFIC Southeast Asia, Petaling Jaya, Selangor, Malaysia

Näf, R., Velluz, A., Brauchli, R. and Thommen, W. (1995) Agarwood oil (Aquilaria agallocha Roxb.). Its composition and eight new valencane-, eremophilane-and vetispirane-derivatives, Flavour and fragrance journal, 10, 147−152.

Ishihara, M., Tsuneya, T. and Uneyama, K. (1993) Components of the agarwood smoke on heating, Journal of Essential Oil Research 5, 419−423.

Ishihara, M., Tsuneya T. and Uneyama, K. (1993) Components of the volatile concentrate of agarwood, Journal of essential oil research: JEOR (USA).

A. Rahman, S.S., Saleh, N.M., Muhammad, N., Clyde, M., Narasivayam, P., Kandasamy, K.I., Jamil, M.A.A., Hassan, N.H., Ismail, H.N.A. and Yahya. M.F. (2014), Enhancement of phytochemical production through in vitro polyploidization of agarwood-producing species, Aquilaria malaccensis, International Journal of Biotechnology Research, 2, 37−43. Enhancement of phytochemical production through in vitro polyploidization of agarwood-producing species, Aquilaria malaccensis.

Compton, J. and Oceania, T. (2002) Agarwood (Gaharu) harvest and trade in New Guinea [Papua New Guinea and the Indonesian province of Papua (formerly Irian Jaya)]. in TRAFFIC Oceania for the Twelfth Meeting of the CITES Plants Committee, with reference to CITES Decisions.

Ismail, N., Rahiman, M.H.F., Taib, M.N., Ali, N.A.M., Jamil, M. and Tajuddin, S.N. (2013) Classification of the quality of agarwood oils from Malaysia using Z-score technique, in System Engineering and Technology (ICSET), 2013 IEEE 3rd International Conference on, IEEE.

Ismail, N., Azah, M.A.N., Jamil, M., Rahiman, M.H.F., Tajuddin, S.N. and Taib, M.N. (2013) Analysis of high quality agarwood oil chemical compounds by means of SPME/GC-MS and Z-score technique, Malaysian Journal of Analytical Sciences, 17, 403-413.

Ismail, N., Rahiman, M.H.F., Taib, M.N., Ali, N. A.M., Jamil, M. and Tajuddin, S.N. (2013) The grading of agarwood oil quality using k-Nearest Neighbor (k-NN), in Systems, Process & Control (ICSPC), 2013 IEEE Conference on, IEEE.

Najib, M.S., Ahmad, M.U., Funk, P., Taib, M.N. and Ali, N.A.M. (2012) Agarwood classification: a case-based reasoning approach based on E-nose, in Signal Processing and its Applications (CSPA), 2012 IEEE 8th International Colloquium on, IEEE.

Najib, M.S., Taib, M.N., Ali, N.A.M., Arip, M.N.M. and Jalil, A.M. (2011) Classification of Agarwood grades using ANN, in Electrical, Control and Computer Engineering (INECCE), 2011 International Conference on, IEEE.

Najib, M.S., Ali, N.A.M., Arip, M.N.M., Jalil, A.M. and Taib, M.N. (2010) Classification of Agarwood region using ANN, in 2010 IEEE Control and System Graduate Research Colloquium (ICSGRC 2010).

Xu, Y., Zhang, Z., Wang, M., Wei, J., Chen, H., Gao, Z., Sui, C., Luo, H., Zhang, X., Yang, Y., Meng, and H. Li, W. (2013) Identification of genes related to agarwood formation: transcriptome analysis of healthy and wounded tissues of Aquilaria sinensis, BMC Genomics, 14, 227.

Zhang, Z., Wei, J. H., Han, X. M., Liang, L., Yang, Y., Meng, H., Xu, Y. H. and Gao, Z. H. (2014) The sesquiterpene biosynthesis and vessel-occlusion formation in stems of Aquilaria sinensis (Lour.) Gilg trees induced by wounding treatments without variation of microbial communities, International Journal of Molecular Science, 15, 23589–23603.

Tamuli, P., Boruah, P., Nath, S.C. and Leclercq, P. (2005) Essential oil of eaglewood tree: a product of pathogenesis, Journal of Essential Oil Researc, 17, 601–604.

Zhang, X.L., Liu, Y.Y., Wei, J.H., Yang, Y., Zhang, Z., Huang, J.Q., Chen, H.Q. Liu, and Y.J. (2012) Production of high-quality agarwood in Aquilaria sinensis trees via whole-tree agarwood-induction technology, Chinese Chem Lett., 23, 727–730.

Tran, Q.L., Tran, Q.K., Kouda, K., Nguyen, N.T., Maruyama, Y., Saiki, I. and Kadota, S. (2003) A survey on agarwood in Vietnam, J. Trad. Med., 20, 173−186.

Cheng, J.T., Han, Y.Q., He, J., De Wu, X., Dong, L.B., Peng, L.Y., Li, Y. and Zhao, Q.S. (2013) Two new tirucallane triterpenoids from the leaves of Aquilaria sinensis, Arch Pharm Res., 36, 1084–1089.

Tamuli, P., Boruah, P. and Samanta, R. (2014) Biochemical changes in agarwood tree (Aquilaria malaccensis Lamk.) during pathogenesis, Journal of Spices and Aromatic Crops, 13.

Yang, L., Qiao, L., Xie, D., Yuan, Y., Chen, N., Dai, J. and Guo, S. (2012) 2-(2-phenylethyl)chromones from Chinese eaglewood, Phytochemistry, 76, 92–97.

Richter, J. and Schellenber, I. (2007) Comparison of different extraction methods for the determination of essential oils and related compounds from aromatic plants and optimization solid-phase microxtraction/gas chromatography, Analytical Bioanalytical Chemistry, 387, 2207–2217.

Tran, T. C. and Marriott, P. J. (2007) Characterization of incense smoke by solid phase micro-extraction - Comprehensive two-dimensional gas chromatography (GC x GC), Atmos Environ., 41, 5756–5768.

Bicchi, C., Cordero, C., Iori, C., Rubiolo, P. and Sandra, P. (2000) Headspace Sorptive Extraction (HSSE) in the headspace analysis of aromatic and medicinal plants, Hrc-J High Res. Chrom., 23, 539–546.

Blanch, G.P., Reglero, G., Herraiz, M. and Tabera, J. (1991) A Comparison of different extraction methods for the volatile components of grape juice, Journal of Chromatographic Science, 29, 11–15.

Chuang, H.C., Jones, T., Chen, Y., Bell, J., Wenger, J. and BeruBe, K. (2011) Characterisation of airborne particles and associated organic components produced from incense burning, Anal. Bioanal. Chem., 401, 3095–3102.

Espinoza, E.O., Lancaster, C.A., Kreitals, N.M., Hata, M., Cody, R.B. and Blanchette, R.A. (2014) Distinguishing wild from cultivated agarwood (Aquilaria spp.) using direct analysis in real time and time of-flight mass spectrometry, Rapid Commun. Mass Spectrom., 28, 281–289.

Gao, Z.H., Wei, J.H., Yang, Y., Zhang, Z. and Zhao, W.T. (2012) Selection and validation of reference genes for studying stress-related agarwood formation of Aquilaria sinensis, Plant Cell Reports, 31, 1759–1768.

Lin, J.M. and Tang, C.S. (1994) Characterization and aliphatic aldehyde content of particulates in Chinese incense smoke, Bull Environ Contam Toxicol., 53, 895–901.

Mirnaghi, F.S. and Pawliszyn, J. (2012) Development of coatings for automated 96-blade solid phase micro-extraction-liquid chromatography-tandem mass spectrometry system, capable of extracting a wide polarity range of analytes from biological fluids, J. Chromatogr. A, 1261, 91–98.

Ali, N.A.M., Ismail, N. and Taib, M.N. (2012) Analysis of agarwood oil (Aquilaria malaccensis) based on GC-MS data, in Signal Processing and its Applications (CSPA), 2012 IEEE 8th International Colloquium on, IEEE.

Blomberg, J., Schoenmakers, P.J., Beens, J. and Tijssen, R. (1997) Compehensive two-dimensional gas chromatography (GC GC) and its applicability to the characterization of complex (petrochemical) mixture, Journal of high resolution chromatograph, 20, 539–544.

Guichard, H., Guichard, E., Langlois, D., Issanchou, S. and Abbott, N. (1995) GC sniffing analysis: olfactive intensity measurement by two methods, Zeitschrift für Lebensmittel-Untersuchung und Forschung, 201, 344–350.

Johnson, K.J. Synovec, R.E. (2002) Pattern recognition of jet fuels: comprehensive GC  GC with ANOVA-based feature selection and principal component analysis, Chemometrics and Intelligent Laboratory Systems, 60, 225–237.

Jordan, M.J., Margaria, C.A., Shaw, P.E. and Goodner, K.L. (2002) Aroma active components in aqueous kiwi fruit essence and kiwi fruit puree by GC-MS and multidimensional GC/GC-O, J. Agric. Food Chem., 50, 5386–5390.

Jordán, M.J., Margaría, C.A., Shaw, P.E. and Goodner, K.L. (2003) Volatile components and aroma active compounds in aqueous essence and fresh pink guava fruit puree (Psidium guajava L.) by GC-MS and multidimensional GC/GC-O, Journal of Agricultural and Food Chemistry, 51, 1421v1426.

Marriott, P.J., Morrison, P.D., Shellie, R.A., Dunn, M.S., Sari, E. and Ryan, D. (2003) Multidimensional and comprehensive - two-dimensional gas chromatography, Lc. Gc. Eur., 16, 23–31.

Marriott, P.J., Haglund, P. and Ong, R.C.Y. (2003) A review of environmental toxicant analysis by using multidimensional gas chromatography and comprehensive GC, Clinica Chimica Acta, 328, 1–19.

Mei, W.L., Yang, D.L., Wang, H., Yang, J.L., Zeng, Y.B., Guo, Z.K., Dong, W.H., Li, W. and Dai, H.F. (2013) Characterization and determination of 2-(2-phenylethyl)chromones in agarwood by GC-MS, Molecules, 18, 12324–12345.

Shellie, R., Marriott, P. and Morrison, P. (2001) Concepts and preliminary observations on the triple-dimensional analysis of complex volatile samples by using GCGC-TOFMS, Analytical Chemistry, 73, 1336–1344.

Villberg, K. and Veijanen, A. (2001) Analysis of a GC/MS thermal desorption system with simultaneous sniffing for determination of off-odor compounds and VOCs in fumes formed during extrusion coating of low-density polyethylene, Anal. Chem., 73, 971–977.

Wang, Q.H., Peng, K., Tan, L.H. and Dai, H.F. (2010) Aquilarin A, a new benzenoid derivative from the fresh stem of Aquilaria sinensis, Molecules, 15, 4011–4016.

Wangchuk, P., Keller, P.A., Pyne, S.G., Taweechotipatr, M. and Kamchonwongpaisan, S. (2013) GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile, Nat. Prod. Commun., 8, 1305–1308.

Welthagen, W., Shellie, R.A., Spranger, J., Ristow, M., Zimmermann, R. and Fiehn, O. (2005) Comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC  GC-TOF) for high resolution metabolomics: biomarker discovery on spleen tissue extracts of obese NZO compared to lean C57BL/6 mice, Metabolomics, 1, 65–73.

Hidayat, W., Shakaff, A.Y.M., Ahmad, M.N. and Adom, A.H. (2010) Classification of Agarwood Oil Using an Electronic Nose, Sensors, 10, 4675–4685.

Alkhathlan, H.Z., Al-Hazimi, H.M., Al-Dhalaan, F.S. and Mousa, A.A. (2005) Three 2-(2-phenylethyl) chromones and two terpenes from agarwood, Nat. Prod. Res., 19, 367–372.

Azah, M.A.N., Ismail, N., Mailina, J., Taib, M.N., Rahiman, M.H.F. Hafizi, Z.M. (2014) Chemometric study of selected agarwood oils by Gas Chromatography-Mass Spectrometry, Journal of Tropical Forest Science, 26, 382–388.

Azah, M.A.N., Husni, S.S., Mailina, J., Sahrim, L., Majid, J.A. and Faridz, Z.M. (2013) Classification of agarwood (Gaharu) by resin content, Journal of Tropical Forest Science, 25, 213–219.

Burfield, T. (2005) Agarwood Chemistry.

Chaudhari, D. (1993) Agarwood from Aquilaria malaccensis, (A. agallocha, Roxb.), MFP News, 3, 12–13.

Chen, H.Q., Wei, J.H., Yang, J.S., Zhang, Z., Yang, Y., Gao, Z.H., Sui, C. and Gong, B. (2012)
Chemical constituents of agarwood originating from the endemic genus Aquilaria plants, Chem Biodivers., 9, 236–250.

Fadzil, A.H.M., Hamid, K.H.K., Rodhi, M.N. M. and Mohd Kamaruddin, L. (2013) Extraction of essential oil from biologically inoculated agarwood, in Business Engineering and Industrial Applications Colloquium (BEIAC), 2013 IEEE, IEEE.

Gao, X.X., Xie, M.R., Liu, S.F., Guo, X.L., Chen, X.Y., Zhong, Z.J., Wang, L. and Zhang, W.M. (2014) Chromatographic fingerprint analysis of metabolites in natural and artificial agarwood using gas chromatography-mass spectrometry combined with chemometric methods, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 967, 264–273.

Ismail, N., Rahiman, M.H.F., Taib, M.N., Ali, N.A. M., Jamil, M. and Tajuddin, S.N. (2013) Analysis of chemical compounds of agarwood oil based on headspace-solid phase micro-extraction combined with gas chromatography mass-spectrometry, in Signal Processing and its Applications (CSPA), 2013 IEEE 9th International Colloquium on, IEEE.

Jong, P.L., Tsan, P. and Mohamed, R. (2014) Gas Chromatography-Mass Spectrometry analysis of agarwood extracts from mature and juvenile Aquilaria malaccensis, International Journal of Agriculture and Biology, 16, 644–648.

Lancaster, C. and Espinoza, E. (2012) Evaluating agarwood products for 2-(2-phenylethyl) chromones using direct analysis in real time time-of-flight mass spectrometry, Rapid Communications in Mass Spectrometry, 26, 2649–2656.

Li, W., Cai, C.H., Dong, W.H., Guo, Z.K., Wang, H., Mei, W.L. and Dai, H.F. (2014) 2-(2-phenylethyl)chromone derivatives from Chinese agarwood induced by artificial holing, Fitoterapia, 98, 117–123.

Nagashima, T. (1984) Agarwood and its components, The Takasago Times, 81, 25–29.

Najib, M., Ali, N., Arip, M., Jalil, A., Taib, M. and Kasuan, N. (2010) Classification of Malaysian and Indonesian Agarwood using k-NN, International Sysmposium on Forestry and Forest Products 2010.

Okudera, Y. and Ito, M. (2009) Production of agarwood fragrant constituents in Aquilaria calli and cell suspension cultures, Plant Biotechnology, 26, 307–315.

Okugawa, H., Ueda, R., Matsumoto, K., Kawanishi, K. and Kato, A. (1993) Effects of agarwood extracts on the central nervous system in mice and Planta. Med., 59, 32–36.

Subasinghe, S.M.C.U.P. and Hettiarachchi, D.S. (2015) Characterisation of agarwood type resin of Gyrinops walla Gaertn growing in selected populations in Sri Lanka, Industrial Crops and Products, 69, 76–79.

Tajuddin, S.N., Muhamad, N.S., Yarmo, M.A. and Yusoff, M.M. (2013) Characterization of the chemical constituents of agarwood oils from Malaysia by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry, Mendeleev Commu., 23, 51–52.

Tian, G. and Haigang, P. (2012) Study on the chemical constituents of volatile oil from tagara agarwood [J], Guangdong Chemical Industry, 4, 139.

Tian, J.-J., Gao, X.-X., Zhang, W.-M., Wang, L. and Qu, L.-H. (2013) Molecular identification of endophytic fungi from Aquilaria sinensis and artificial agarwood induced by pinholes-infusion technique, African Journal of Biotechnology, 12, 3115–3131.

Wu, B., Kwon, S. W., Hwang, G. S. and Park, J. H. (2012) Eight new 2-(2-phenylethyl) chromone (= 2-(2-phenylethyl)-4H-1-benzopyran-4-one) derivatives from Aquilaria malaccensis Agarwood, Helvetica Chimica Acta, 95, 1657–1665.

Yang, D.L., Wang, H., Guo, Z.K., Dong, W.H., Mei, W.L. and Dai, H.F. (2014) A new 2-(2-phenylethyl)chromone derivative in Chinese agarwood 'Qi-Nan' from Aquilaria sinensis, Journal of Asian Natural Products Research, 16, 770–776.

Pawliszyn, J. (2012) Handbook of Solid Phase Micro-extraction., Elsevier Inc, USA.

Jain, T.C.B. and S.C. Bhattacharyya (1959) Structure, stereochemistry and absolute configuration of agarol, a new sesquiterpene alcohol from agarwood oil, Tetrahedron Letters, 1, 13–17.

Maheshwari, M., Jain, T., Bates, R. and Bhattacharyya, S. (1963) Terpenoids—xli: Structure and absolute configuration of α-agarofuran,Ц-agarofuran and dihydroagarofuran, Tetrahedron, 19, 1079–1090.

Maheshwari, M., Varma, K. and Bhattacharyya, S. (1963) Terpenoids—XLVII: Structure and absolute configuration of norketoagarofuran, 4-hydroxydihydroagarofuran, 3, 4-dihydroxydi-hydroagarofuran and conversion of β-agarofuran to α-agarofuran, Tetrahedron, 19, 1519–1525.

Pant, P. and Rastogi, R. (1980) Agarol, a new sesquiterpene from Aquilaria agallocha, Phytochemistry, 19, 1869–1870.

Bhandari, P., Pant, P. and Rastogi, R. (1982) Aquillochin, a coumarinolignan from Aquilaria agallocha, Phytochemistry, 21, 2147–2149.

Yoshii, E., Koizumi, T., Oribe, T., Takeuchi, F. and Kubo, K. (1978) The structure of agarotetrol, a novel highly oxygenated chromone from agarwood (jinko), Tetrahedron Letters, 19, 3921–3924.

Meier, M., Kohlenberg, B. and Braun, N. A. (2003) Isolation of anisyl acetone from agarwood oil, Journal of Essential Oil Research, 15, 54–56.

Yoneda, K., Yamagata, E., Nakanishi, T., Nagashima, T., Kawasaki, I., Yoshida, T., Mori, H. and Miura, I. (1984) Sesquiterpenoids in two different kinds of agarwood, Phytochemistry, 23, 2068–2069.

Nakanishi, T., Inada, A., Nishi, M., Yamagata, E. and Yoneda, K. (1986) A new and a known derivatives of 2-(2-phenylethyl) chromone from a kind of agarwood ("Kanankoh," in Japanese) originating from Aquilaria agallocha, Journal of Natural Products, 49, 1106–1108.

Ishihara, M., Tsuneya, T., Shiga, M. and Uneyama, K. (1991) Three sesquiterpenes from agarwood, Phytochemistry, 30, 563–566.

Ishihara, M., Tsuneya, T. and Uneyama, K. (1991) Guaiane sesquiterpenes from agarwood, Phytochemistry, 30, 3343–3347.

Ishihara, M., Tsuneya, T. and Uneyama, Phytochemistry, 33, 1147–1155.

Ueda, J.Y., Imamura, L., Tezuka, Y., Tran, Q.L., Tsuda, M. and Kadota, S. (2006) New sesquiterpene from Vietnamese agarwood and its induction effect on brain-derived neurotrophic factor mRNA expression in vitro, Bioorg. Med. Chem 14, 3571–3574.

Näf, R., Velluz, A., Busset, N. and Gaudin, J. M. (1992) New Nor-sesquiterpenoids with 10-epi-eudesmane skeleton from agarwood (Aquilaria agallocha Roxb.), Flavour and fragrance journal, 7, 295–298.

Nor Azah, M.A., Chang, Y.S., Mailina, J., AbuSaid, A., AbdMajid, J., Saidatul Husni, S., Nor Hasnida, H. and Nik Yasmin, Y. (2008) Comparison of chemical profiles of selected gaharu oils from peninsular Malaysia, Malaysian Journal of Analytical Sciences, 12, 338–340.

Ismail, N., Ali, N.A.M., Jamil, M., F. Rahiman, M. H., .S.N., T. and Taib. M.N. (2008) comparison of chemical profiles of selected Gaharu oils from peninsular Malaysia, The Malyasian Journal of Analytical Sciences, 12, 338–340.

Nakanishi, T., Yamagata, E., Yoneda, K. and Miura, I. (1981) Jinkohol, a prezizane sesquiterpene alcohol from agarwood, Phytochemistry, 20, 1597–1599.

Nakanishi, T., Yamagata, E., Yoneda, K., Miura, I. and Mori, H. (1983) Jinkoh-eremol and jinkohol II, two new sesquiterpene alcohols from agarwood, Journal of the Chemical Society, Perkin Transactions 1, 601–604.

Nakanishi, T., Yamagata, E., Yoneda, K., Nagashima, T., Kawasaki, I., Yoshida, T., Mori, H. and Miura, I. (1984) Three fragrant sesquiterpenes of agarwood, Phytochemistry, 23, 2066–2067.

Shimada, Y., Tominaga, T., Konishi, T. and Kiyosawa., S. (1982) Studies on the agarwood (Jinko). I. Structures of 2-(2-phenylethyl) chromone derivatives, Chemical and Pharmaceutical Bulletin, 30, 3791–3795.

Keijihashimoto, Sachikonakahara, Takehisainoue, Yoshiosumida, Mutsukotakahasm and Yoshiromasada (1985) A new chromone from agarwood and pyrolysis products of chromone derivatives, Chemical and Pharmaceutical Bulletin, 33, 5088–5091.

Shimada, Y., Tominaga, T., Konishi, T. and Kiyosawa., S. (1986) Studies on the agalwood (Jinko). VI Structures of three 2-(2-phenylethyl)-5, 6, 7, 8-tetrahydrochromone derivatives, AH1A, AH2a and AH2b, Chemical and Pharmaceutical Bulletin, 34, 3033–3037.

Shimada, Y., Tominaga, T., Konishi, T., Kiyosawa., S. Y., Fujwara, A., Sugimoto, and Iwagoe, K. (1988) Studies on the agalwood (jinko). VII. Structures of phenylethylchromone derivatives AH7, AH8 and AH9, Chemical and Pharmaceutical Bulletin, 36, 2417–2422.

Shimada, Y., Tominaga, T., Konishi, T., Kiyosawa., S., Fujwara, Y., Sugimoto, A. and Iwagoe, K. (1991) Studies on agalwood (Jinko). X. Structures of 2-(2-phenylethyl) chromone derivatives, Chemical and Pharmaceutical Bulletin, 39, 207–209.

Wu, B., Lee, J. G., Lim, C. J., Jia, S. D., Kwon, S. W., Hwang, G. S. and Park, J. H. (2012) Sesquiterpenoids and 2-(2-Phenylethyl)-4H-chromen-4-one (= 2-(2-
Phenylethyl)-4H-1-benzopyran-4-one) Derivatives from Aquilaria malaccensis Agarwood, Helvetica Chimica Acta, 95, 636–642.

Wetwitayaklung, P., Thavanapong, N. and Charoenteeraboon, J. (2009) Chemical constituents and antimicrobial activity of essential oil and extracts of heartwood of Aquilaria crassna obtained from water distillation and supercritical fluid carbon dioxide extraction, Silpakorn University Science and Technology Journal, 3, 25–33.

Yang, J.S. and Chen, Y.W. (1983) Studies on the constituents of Aquilaria sinensis (Lour.) Gilg. I. Isolation and structure elucidation of two new sesquiterpenes, baimuxinic acid and baimuxinal, Yao Xue Xue Bao, 18, 191–198.

Yang, J., Wang, Y., Su, Y., He, C., Zheng, Q. and Yang, J. (1989) Studies on the Chemical cnstituents of Aquilaria Sinensis (Lour.) Gilg. Ⅲ. Elucidation of the structure of isobaimuxinol and isolation and identification of the constituents of lower boiling fraction of the volatile oil [J], Acta Pharmaceutica Sinica, 4, 005.

Mei, W.-L., Zeng, Y.-B., Wu, J., Cui, H.-B. and Dai, H.-F. (2008) Chemical composition and anti-MRSA activity of the essential oil from Chinese eaglewood, J. Chin. Pharm. Sci., 17, 5.

Yang, J.S. and Chen, Y.W. (1986) Studies on the chemical constituents of Aquilaria sinensis (Lour.) Gilg. II. Isolation and structure of baimuxinol and dehydrobaimuxinol, Yao Xue Xue Bao, 21, 516–520.

Iwago, K., Kakae, T., Konishi, T., Kiyosawa, S., Fujiwara, Y., Shimada, Y., Miyahara, K. and Kawasak, T. (1989) Studies on the agalwood (Jinko). VIII. Structures of bi-phenylethylchromone derivatives, Chemical and Pharmaceutical Bulletin, 37, 124–128.

Yagura, T., Ito, M., Kiuchi, F., Honda, G. and Shimada, Y. (2003) Four new 2-(2-phenylethyl)chromone derivatives from withered wood of Aquilaria sinensis, Chem. Pharm. Bull. Tokyo, 51, 560–564.

Dai, H.F., Liu, J., Zeng, Y.B., Han, Z., Wang, H. and Mei, W.L. (2009) A new 2-(2-phenylethyl)chromone from Chinese eaglewood, Molecules, 14, 5165–5168.

Dai, H.F., Liu, J., Han, Z., Zeng, Y.B., Wang, H. and Mei, W.L. (2010) Two new 2-(2-phenylethyl)chromones from Chinese eaglewood, J. Asian Nat. Prod. Res., 12, 134–137. 

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