Chemical Constituents of Excoecaria agallocha L. (Euphorbiaceae) Growing in Vietnam

Chemical Constituents of Excoecaria agallocha L. (Euphorbiaceae) Growing in Vietnam
T. M. Tran, T. H. Tran, T. T. H. Dinh and D. T. Vu

Three known triterpenoids,  taraxer-14-ene-3-one (1), taraxer-14-ene-3α-ol (2), taraxer-14-ene-3β-ol (3) and one known acylated steroid glucoside, stigmast-5-en-3β-yl (6’-O-heptadecanoyl-β-D-glucopyranoside) (4) were isolated from the n-hexane fraction of methanol extract of the leavesof Excoecaria agallocha L. collected in the Thai Binh province,Vietnam. Their structures were elucidated on the basis of spectroscopic data and by comparison with their spectral data reported in literature. This is the first isolation of compound 4 from this species.

Key words: Excoecaria agallocha L.; triterpenoid; taraxer-14-ene-3-one; taraxer-14-ene-3α-ol; taraxer-14-ene-3β-ol; acylated steroid glucoside; stigmast-5-en-3β-yl (6’-O-heptadecanoyl-β-D-glucopyranoside); methanol; n-hexane fraction


Thirunavukkarasu, P., Ramkumar, L. and Ramanathan, T. (2009) Anti-ulcer activity of Excoecaria agallocha bark on NSAID-induced gastric ulcer in Albino Rat, Global Journal of Pharmacology, 3 (3), 123–126.

Patil, R.C., Manohar, S.M., Upadhye, M.V., Katchi, V.I., Rao, A.J., Mule, A. and Moghe, A.S. (2011) Anti Reverse transcriptase and anticancer activity of stem ethanol extracts of Excoecaria agallocha (Euphorbiaceae), Ceylon Journal of Science (Bio. Sci.), 40 (2), 147–155.

Hoang, H.P. (2000) An Illustrated Flora of Vietnam, 2. Young Publishing, Mekong Printing.

Zou, J.-H., Dai, J., Chen, X. and Yuan, J.-Q. (2006) Pentacyclic triterpenoids from leaves of Excoecaria agallocha, Chemical and Pharmaceutical Bulletin, 54 (6), 920–921.

Nana, F., Sandjo, L.P., Keumedjio, F., Ambassa, P., Malik, R., Kuete, V., Rincheval, V., Choudhary, M.I. and Ngadjui, B.T. (2012) Ceramides and cytotoxic constituents from Ficus glumosa Del. (Moraceae), Journal of the Brazilian Chemical Society, 23 (3), 482–487.

Chen, L., Wang, J.-J., Zhang, G.-G., Song, H.-T. and Qin, L.-P. (2009) A new cerebroside from Gynura divaricata, Natural Product Research, 23, 1330–1336.

Ragasa, C.Y. and Cornelio, K.B. (2013) Triterpenes from Euphorbia hirta and their cytotoxicity, Chinese Journal of Natural Medicines, 11(5), 0528−0533.

Rahman, A.-U., Sultana, N., Akhter, F., Nighat, F. and Choudhary, M.I. (1997) Phytochemical studies on Adhatoda vasica Nees, Natural Product Letters, 10, 249–256.

Sakurai, N., Yaguchi, Y. and Inoue, T. (1987) Triterpenoids from Myrzca rubra, Phytochemistry, 26 (1), 217–219.

Yao, X., Li, G., Bai, Q, Xu, H. and Lü, C. (2013) Taraxerol inhibits LPS-induced inflammatory responses through suppression of TAK1 and Akt activation, International Immunopharmacology, 15, 316–324.

back to top